The Identification of Novel Small Molecule Inhibitors of West Nile Virus Infection 1 2
نویسندگان
چکیده
The Identification of Novel Small Molecule Inhibitors of West Nile Virus Infection 1 2 Amine O. Noueiry, Paul D. Olivo, Urszula Slomczynska, Yi Zhou, Ben Buscher, Brian 3 Geiss, Michael Engle, Robert M. Roth, Kyung Min Chung, Melanie Samuel, and Michael 4 S. Diamond 5 6 Apath, LLC, St Louis, MO 63141 Departments of Medicine, Molecular Microbiology, 7 Pathology & Immunology, Washington University School of Medicine, St. Louis, MO. 8
منابع مشابه
Identification and biochemical characterization of small-molecule inhibitors of west nile virus serine protease by a high-throughput screen.
West Nile virus and dengue virus are mosquito-borne flaviviruses that cause a large number of human infections each year. No vaccines or chemotherapeutics are currently available. These viruses encode a serine protease that is essential for polyprotein processing, a required step in the viral replication cycle. In this study, a high-throughput screening assay for the West Nile virus protease wa...
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West Nile virus (WNV) has spread throughout the United States and Canada and now annually causes a clinical spectrum of human disease ranging from a self-limiting acute febrile illness to acute flaccid paralysis and lethal encephalitis. No therapy or vaccine is currently approved for use in humans. Using high-throughput screening assays that included a luciferase expressing WNV subgenomic repli...
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